Nef as a Proliferative Factor for Kidney Epithelial Cells in HIV-Associated Nephropathy
نویسندگان
چکیده
Introduction HIV-associated nephropathy (HIVAN) is the leading cause of end-stage renal disease in patients with HIV-1 infection. While HIVAN involves all portions of the kidney, marked changes in podocyte proliferation and dedifferentiation are central to the pathogenesis of this disease. This review focuses on identifying the genes and signaling pathways that trigger terminally differentiated quiescent podocytes to lose their normal markers of maturity and reenter the cell cycle. The parallels between these alterations to malignant transformation are quite striking.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2008